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Your Weekly Dose of Proteins, Week 2

October 9, 2011

Your Weekly Dose of Proteins, Week 2

 

Today we will talk about a protein known as TolB. TolB is part of a larger multi-protein complex known as Tol-Pal. If I recall correctly, the Tol-Pal system is composed of about five different protein components. See the image below for a space-fill model of TolB and its association with Pal.

TolB and its association with Pal. The green guy is TolB, while the purple guy is Pal.

The neat thing about the Tol-Pal system is that its function isn’t quite known. This is neat because it means that there’s room for research here to uncover its exact function.

 

Nevertheless, there are several proposed functions of Tol-Pal:

  • The Tol-Pal system may be involved in the integrity of the outer membrane of the bacterial cell.
  • It might anchor down the outer membrane to the peptidoglycan layer.

 

 

Incidentally, parts of the Tol-Pal system share structural (and weak sequence) similarity with MotA and MotB, the motor components of the bacterial flagellum. Again, this is a topic to be discussed in a later article. In the meantime, don’t forget to take your weekly dose of proteins!

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